A nine-year-old girl in London and a man and a girl in West Yorkshire have all died after contracting swine flu.
The child from south London, who died at the weekend, had "serious underlying health problems," as did the other two victims who are from Kirklees.
The girl from Kirklees died on Thursday, three days before the man. None of the victims has been named.
The latest deaths take the number of swine flu sufferers who have died in the UK to seven.
A spokesperson for NHS Kirklees said: "At this stage, we have no confirmation whether or not swine flu was the cause of death."
Last week a 19-year-old man from south London, also with underlying health problems, died after contracting the virus.
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