Emergency crews were called to the semi-detached property in Gwent Gardens, in the Townhill area, shortly after 1800 BST on Thursday
South Wales Police confirmed five people, including two firefighters, were taken to hospital suffering from burns and smoke inhalation.
The cause of the blaze is unknown at this stage
A police spokesman said there was no more information about the deceased or the conditions of the injured at this stage.
Assistant chief fire officer Wyn Edwards, of Mid and West Wales Fire and Rescue Service, said of the injured firefighters: "They were faced with a very serious fire in the property, with flames escaping from the windows and doors.
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